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Necrox-5 methanesulfonate

CAS No. 1383718-29-3

Necrox-5 methanesulfonate ( Necrosis inhibitor 5 )

Catalog No. M11590 CAS No. 1383718-29-3

NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Necrox-5 methanesulfonate
  • Note
    Research use only, not for human use.
  • Brief Description
    NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.
  • Description
    NecroX-5 is a novel necroptosis inhibitor that reduces mitochondrial oxidative stress, prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter; improves mitochondrial oxygen consumption, and suppresses mitochondrial Ca(2+) overload during reoxygenation in an in vitro rat heart HR model, reduces the ouabain- or histamine-induced increase in mitochondrial Ca(2+).
  • Synonyms
    Necrosis inhibitor 5
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1383718-29-3
  • Formula Weight
    645.80
  • Molecular Formula
    C27H39N3O9S3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 170 mg/mL 263.24 mM
  • SMILES
    CS(=O)(=O)O.CS(=O)(=O)O.C1COCCC1CNC2=CC(=CC3=C2NC(=C3)C4=CC=CC=C4)CN5CCS(=O)(=O)CC5
  • Chemical Name
    5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-7-amine, dimethanesulfonate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Thu VT, et al. Cardiovasc Res. 2012 May 1;94(2):342-50.
2. Li X, et al. Allergy. 2016 Feb;71(2):198-209.
3. Park JH, et al. Int J Oncol. 2017 Jan;50(1):185-192.
4. Thu VT, et al. Korean J Physiol Pharmacol. 2016 Mar;20(2):201-11.
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